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2014

Yannick Doyon, PhD

Department of Molecular Medicine, Université Laval In vivo genome editing as a novel class of human therapeutics to treat pediatric metabolic disorders Genetic disorders in children are individually rare but collectively frequent, affecting the lives of approximately 500,000 children in Canada. They often are serious, life threatening or fatal, but because each rare disease affects…

2014

Jennifer Heisz, PhD

Department of Kinesiology, McMaster University Examining the dose-response relationship between physical exercise and cognitive function in older adults Alzheimer’s disease is the most common form of dementia, causing severe cognitive impairment and interfering with daily life. As the population ages, the number of Canadians living with dementia is projected to double within a generation to…

2014

Jeffrey Leyton, PhD

Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke An advanced development in targeted radiation against muscle invasive migrating bladder cancer cells Bladder cancer affects thousands of Canadians on an annual basis. Unfortunately, bladder cancer remains one of the most difficult cancers to manage. The treatment options currently available to patients with muscle invasive bladder…

2014

Ewa Niechwiej-Szwedo, PhD

Department of Kinesiology, University of Waterloo The role of binocular vision in the development of fine motor skills Seeing in depth is essential for guiding purposeful movements, such as reaching and grasping for toys or food, catching a ball or using tools to accomplish complex tasks. Binocular vision provides important cues for 3D depth perception.…

2014

Emanuel Rosonina, PhD

Department of Biology, York University Regulation of transcription and splicing factors by sumoylation SUMO is a protein modification that plays important roles in regulating many cellular processes. Several proteins that are involved in neurodegenerative disease are modified by SUMO, and abnormal protein modifications by SUMO have been implicated in many types of cancer, indicating that…

2013

Craig Bailey, PhD

Department of Biomedical Sciences, University of Guelph Nicotinic receptor signaling in a mouse model of Fetal Alcohol Spectrum Disorder Chronic prenatal exposure to alcohol can produce a spectrum of adverse effects known collectively as Fetal Alcohol Spectrum Disorder (FASD). Although deficits in attention rank among the most common and persistent components of FASD, mechanisms underlying…

David Chatenet, PhD
2013

David Chatenet, PhD

Centre INRS–Institut Armand-Frappier Design and synthesis of peptide inhibitors of PqsE as novel antibacterial therapeutics Pseudomonas aeruginosa (Pa), a prevalent opportunistic human pathogen responsible for morbidity and mortality among individuals suffering from cystic fibrosis, is notorious for its high resistance to antibiotic treatments.

2013

Margaret K Hahn, MD PhD

Centre for Addiction and Mental Health Central insulin to prevent olanzapine-induced adiposity: a rodent model Atypical antipsychotic (AAP) medications, the mainstay treatment for psychosis and schizophrenia, are defined by weight gain and metabolic problems that likely contribute to a 2-fold increase in cardiovascular (CV) deaths in this population.

2013

Pierre-Yves Lozach, PhD

Centre INRS – Institut Armand-Frappier Bunyavirus entry into mammalian cells Bunyaviridae is a large family of viruses mainly transmitted by arthropods such as mosquitos and ticks. Many bunyaviruses are important pathogens in humans and livestock. Due to their mode of transmission, they are considered emerging agents of diseases. Unfortunately, bunyaviruses are understudied, which has contributed to…

2013

Dave Richard, PhD

Département de microbiologie-infectiologie et d’immunologie, Université Laval Protein trafficking to the apical complex of the malaria parasite Malaria is one of the world’s most common infectious diseases, with approximately 274 million cases each year and 1 million deaths, and thus represents one of the most devastating global public health problems.

2013

Marie-Ève Tremblay, PhD

Département de médecine moléculaire, Université Laval Microglial relationships with synaptic elements in Alzheimer’s disease A series of recent discoveries have challenged our view of microglia, the brain immune cells, showing unexpected roles in the active maintenance of neuronal circuits throughout the lifespan. Contributing to this nascent field of investigation, this project aims at exploring the…

2012

Alexandre Douplik, PhD

Physics Department, Ryerson University Surface-enhanced Raman fiber sensor for endoscopic early detection of tumor-related biomolecules in gastroenterology The goal of the project is development of surface-enhanced Raman spectroscopy fiber probes for high sensitive and rapid non-invasive diagnostics including malignancy detection. Optical sampling of biological molecules can detect specific Raman “fingerprints” including cancer “signatures” with high…