Rebecca Shapiro, PhD

Department of Molecular and Cellular Biology, University of Guelph

Genetic and functional genomic analysis of antifungal drug resistance in Candida auris

Rebecca Shapiro, PhD
Rebecca Shapiro, PhD, recipient of a 2018 Banting Research Foundation Discovery Award

Combating infectious disease pathogens is a pressing global health challenge. Due to limited treatment options, fungal pathogens pose a unique challenge, and are emerging as a leading cause of human mortality. The proposed research program will develop and use cutting-edge CRISPR-based technologies to study fungal disease. Candida auris is an emerging fungal pathogen that is highly resistant to antifungal drugs, and a critical threat to public health. Dr Shapiro’s group will quantify drug resistance in clinical isolates of C. auris and use whole-genome sequencing to identify genetic mutations associated with resistance. They will then develop CRISPR systems to create genetic mutants on a large scale, and use these to explore genetic mechanisms by which C. auris can tolerate antifungal drugs and cause life-threatening disease.

The Shapiro lab
In the Shapiro lab