Department of Medicine, Université Laval Impact of a lifestyle modification program on high-density lipoprotein function Plasma levels of high-density lipoprotein (HDL) cholesterol, often referred to as “the good cholesterol”, are inversely associated with cardiovascular disease and type 2 diabetes risk. Several lines of evidence suggest that these associations could be explained by the fact that…
Yannick Doyon, PhD
Department of Molecular Medicine, Université Laval In vivo genome editing as a novel class of human therapeutics to treat pediatric metabolic disorders Genetic disorders in children are individually rare but collectively frequent, affecting the lives of approximately 500,000 children in Canada. They often are serious, life threatening or fatal, but because each rare disease affects…
Jennifer Heisz, PhD
Department of Kinesiology, McMaster University Examining the dose-response relationship between physical exercise and cognitive function in older adults Alzheimer’s disease is the most common form of dementia, causing severe cognitive impairment and interfering with daily life. As the population ages, the number of Canadians living with dementia is projected to double within a generation to…
Jeffrey Leyton, PhD
Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke An advanced development in targeted radiation against muscle invasive migrating bladder cancer cells Bladder cancer affects thousands of Canadians on an annual basis. Unfortunately, bladder cancer remains one of the most difficult cancers to manage. The treatment options currently available to patients with muscle invasive bladder…
Ewa Niechwiej-Szwedo, PhD
Department of Kinesiology, University of Waterloo The role of binocular vision in the development of fine motor skills Seeing in depth is essential for guiding purposeful movements, such as reaching and grasping for toys or food, catching a ball or using tools to accomplish complex tasks. Binocular vision provides important cues for 3D depth perception.…
Emanuel Rosonina, PhD
Department of Biology, York University Regulation of transcription and splicing factors by sumoylation SUMO is a protein modification that plays important roles in regulating many cellular processes. Several proteins that are involved in neurodegenerative disease are modified by SUMO, and abnormal protein modifications by SUMO have been implicated in many types of cancer, indicating that…
