Department of Medicine, Université Laval Targeting ErbB2 by TAK-165 reverses pulmonary hypertension in vitro and in vivo In pulmonary hypertension (high blood pressure in the lungs), cells forming the walls of arteries in the lungs proliferate like cancer cells, narrowing the arteries and making it difficult for blood to pass through. There is also evidence…
Benoît Arsenault, PhD
Department of Medicine, Université Laval Impact of a lifestyle modification program on high-density lipoprotein function Plasma levels of high-density lipoprotein (HDL) cholesterol, often referred to as “the good cholesterol”, are inversely associated with cardiovascular disease and type 2 diabetes risk. Several lines of evidence suggest that these associations could be explained by the fact that…
Yannick Doyon, PhD
Department of Molecular Medicine, Université Laval In vivo genome editing as a novel class of human therapeutics to treat pediatric metabolic disorders Genetic disorders in children are individually rare but collectively frequent, affecting the lives of approximately 500,000 children in Canada. They often are serious, life threatening or fatal, but because each rare disease affects…
Dave Richard, PhD
Département de microbiologie-infectiologie et d’immunologie, Université Laval Protein trafficking to the apical complex of the malaria parasite Malaria is one of the world’s most common infectious diseases, with approximately 274 million cases each year and 1 million deaths, and thus represents one of the most devastating global public health problems.
Marie-Ève Tremblay, PhD
Département de médecine moléculaire, Université Laval Microglial relationships with synaptic elements in Alzheimer’s disease A series of recent discoveries have challenged our view of microglia, the brain immune cells, showing unexpected roles in the active maintenance of neuronal circuits throughout the lifespan. Contributing to this nascent field of investigation, this project aims at exploring the…
Martin Lévesque, PhD
Department of Psychiatry and Neurosciences, Université Laval Molecular mechanisms of axon guidance mediated by PlexinC1 in dopamine neuron axonal projections Degeneration of midbrain dopaminergic neurons (mDA) is the principal cause of Parkinson’s disease. Grafts of dopaminergic neurons newly generated from stem cells represent a promising therapeutic avenue. However, inappropriate re-innervation of the grafted neurons represents…
