Department of Biology,
York University –
Regulation of transcription and splicing factors by sumoylation
SUMO is a protein modification that plays important roles in regulating many cellular processes. Several proteins that are involved in neurodegenerative disease are modified by SUMO, and abnormal protein modifications by SUMO have been implicated in many types of cancer, indicating that tight regulation of this modification is critical to preventing disease.
Dr Rosonina is interested in studying how cells use SUMO modifications to control the expression of genes under normal conditions, and how abnormal SUMO modifications, like those associated with cancer, result in inappropriate expression of some genes. He expects the results of his work to add significantly to our understanding of gene expression in normal and disease situations.