Department of Psychiatry and Neurosciences, Université Laval Molecular mechanisms of axon guidance mediated by PlexinC1 in dopamine neuron axonal projections Degeneration of midbrain dopaminergic neurons (mDA) is the principal cause of Parkinson’s disease. Grafts of dopaminergic neurons newly generated from stem cells represent a promising therapeutic avenue. However, inappropriate re-innervation of the grafted neurons represents…
Michelle Scott, PhD
Department of Biochemistry, Université de Sherbrooke Characterization of a novel function of small RNAs in alternative splicing The process of alternative splicing allows the production of multiple distinct proteins from a single gene, in a manner that can be cell-type specific. Alternative splicing requires an extensive and complex regulation. Diverse human diseases can be caused…
Marcelo Berlim, MD
Department of Psychiatry, McGill University Remediating decision-making deficits in depressed subjects at high risk for suicide with transcranial magnetic stimulation We aim to assess whether high frequency repetitive transcranial magnetic stimulation, a safe and non-invasive method for modulating the activity of specific brain regions, when applied over the left region of the forehead (ie, the…
Simon Lees, PhD
Faculty of Medicine, Lakehead University The IL-6 paradox in the development of insulin resistance Paradoxically, elevated IL-6 is associated with insulin resistance and type 2 diabetes, while at the same time strong evidence supports the notion that IL-6 may facilitate improved insulin signaling as a result of physical activity.
Tara Moriarty, PhD
Matrix Dynamics Group, Faculty of Dentistry, University of Toronto Vascular adhesion mechanisms of the Lyme disease spirochete Blood-borne spread (dissemination) of pathogens is a critical step in the development of serious infectious disease, and is responsible for most of the mortality due to bacterial infection. The dissemination mechanisms of many bacterial pathogens are largely unknown.
Takako Niikura, DVM PhD
Faculty of Health Sciences, Simon Fraser University Regulation of amyloid beta metabolism In Alzheimer’s disease (AD), progressive brain atrophy and dementia appear because of neuronal cell death and synaptic dysfunction in brains. Amyloid beta plays a central toxic role in AD pathogenesis.
Jonathan Perreault, PhD
INRS – Institut Armand Frappier Regulation in the opportunistic pathogen Burkholderia by the MAEB RNA motif Aside from their role in storing hereditary information, DNA and RNA are now known to have many more functions. Living organisms have a plethora of RNAs that control numerous processes in cells. One such RNA, named MAEB, was recently…
