Physics Department, Ryerson University Surface-enhanced Raman fiber sensor for endoscopic early detection of tumor-related biomolecules in gastroenterology The goal of the project is development of surface-enhanced Raman spectroscopy fiber probes for high sensitive and rapid non-invasive diagnostics including malignancy detection. Optical sampling of biological molecules can detect specific Raman “fingerprints” including cancer “signatures” with high…
Carl Ernst, PhD
Department of Psychiatry, McGill University Functional analysis of the 16p11.2 locus using patient-derived induced-pluripotent stem cells Large deletions of DNA on chromosome 16 are associated with Autism Spectrum Disorders (ASD) in about 1% of all Canadians with autism, and many more Canadians with intellectual disability. I have recruited and clinically assessed two independent families carrying…
Dennis Jensen, PhD
Department of Kinesiology & Physical Education, McGill University Physiological mechanisms of dyspnea relief and improved exercise tolerance after treatment with oral morphine in patients with advanced chronic obstructive pulmonary disease (COPD) Chronic obstructive pulmonary disease (COPD) is a progressive disease of the lungs and airways, causing shortness of breath (dyspnea) and exercise intolerance. Conventional efforts…
Martin Lévesque, PhD
Department of Psychiatry and Neurosciences, Université Laval Molecular mechanisms of axon guidance mediated by PlexinC1 in dopamine neuron axonal projections Degeneration of midbrain dopaminergic neurons (mDA) is the principal cause of Parkinson’s disease. Grafts of dopaminergic neurons newly generated from stem cells represent a promising therapeutic avenue. However, inappropriate re-innervation of the grafted neurons represents…
Michelle Scott, PhD
Department of Biochemistry, Université de Sherbrooke Characterization of a novel function of small RNAs in alternative splicing The process of alternative splicing allows the production of multiple distinct proteins from a single gene, in a manner that can be cell-type specific. Alternative splicing requires an extensive and complex regulation. Diverse human diseases can be caused…
