Department of Biology, York University Regulation of transcription and splicing factors by sumoylation SUMO is a protein modification that plays important roles in regulating many cellular processes. Several proteins that are involved in neurodegenerative disease are modified by SUMO, and abnormal protein modifications by SUMO have been implicated in many types of cancer, indicating that…
Craig Bailey, PhD
Department of Biomedical Sciences, University of Guelph Nicotinic receptor signaling in a mouse model of Fetal Alcohol Spectrum Disorder Chronic prenatal exposure to alcohol can produce a spectrum of adverse effects known collectively as Fetal Alcohol Spectrum Disorder (FASD). Although deficits in attention rank among the most common and persistent components of FASD, mechanisms underlying…
David Chatenet, PhD
Centre INRS–Institut Armand-Frappier Design and synthesis of peptide inhibitors of PqsE as novel antibacterial therapeutics Pseudomonas aeruginosa (Pa), a prevalent opportunistic human pathogen responsible for morbidity and mortality among individuals suffering from cystic fibrosis, is notorious for its high resistance to antibiotic treatments.
Margaret K Hahn, MD PhD
Centre for Addiction and Mental Health Central insulin to prevent olanzapine-induced adiposity: a rodent model Atypical antipsychotic (AAP) medications, the mainstay treatment for psychosis and schizophrenia, are defined by weight gain and metabolic problems that likely contribute to a 2-fold increase in cardiovascular (CV) deaths in this population.
Pierre-Yves Lozach, PhD
Centre INRS – Institut Armand-Frappier Bunyavirus entry into mammalian cells Bunyaviridae is a large family of viruses mainly transmitted by arthropods such as mosquitos and ticks. Many bunyaviruses are important pathogens in humans and livestock. Due to their mode of transmission, they are considered emerging agents of diseases. Unfortunately, bunyaviruses are understudied, which has contributed to…
Dave Richard, PhD
Département de microbiologie-infectiologie et d’immunologie, Université Laval Protein trafficking to the apical complex of the malaria parasite Malaria is one of the world’s most common infectious diseases, with approximately 274 million cases each year and 1 million deaths, and thus represents one of the most devastating global public health problems.
Marie-Ève Tremblay, PhD
Département de médecine moléculaire, Université Laval Microglial relationships with synaptic elements in Alzheimer’s disease A series of recent discoveries have challenged our view of microglia, the brain immune cells, showing unexpected roles in the active maintenance of neuronal circuits throughout the lifespan. Contributing to this nascent field of investigation, this project aims at exploring the…
Alexandre Douplik, PhD
Physics Department, Ryerson University Surface-enhanced Raman fiber sensor for endoscopic early detection of tumor-related biomolecules in gastroenterology The goal of the project is development of surface-enhanced Raman spectroscopy fiber probes for high sensitive and rapid non-invasive diagnostics including malignancy detection. Optical sampling of biological molecules can detect specific Raman “fingerprints” including cancer “signatures” with high…
Carl Ernst, PhD
Department of Psychiatry, McGill University Functional analysis of the 16p11.2 locus using patient-derived induced-pluripotent stem cells Large deletions of DNA on chromosome 16 are associated with Autism Spectrum Disorders (ASD) in about 1% of all Canadians with autism, and many more Canadians with intellectual disability. I have recruited and clinically assessed two independent families carrying…
Dennis Jensen, PhD
Department of Kinesiology & Physical Education, McGill University Physiological mechanisms of dyspnea relief and improved exercise tolerance after treatment with oral morphine in patients with advanced chronic obstructive pulmonary disease (COPD) Chronic obstructive pulmonary disease (COPD) is a progressive disease of the lungs and airways, causing shortness of breath (dyspnea) and exercise intolerance. Conventional efforts…
Martin Lévesque, PhD
Department of Psychiatry and Neurosciences, Université Laval Molecular mechanisms of axon guidance mediated by PlexinC1 in dopamine neuron axonal projections Degeneration of midbrain dopaminergic neurons (mDA) is the principal cause of Parkinson’s disease. Grafts of dopaminergic neurons newly generated from stem cells represent a promising therapeutic avenue. However, inappropriate re-innervation of the grafted neurons represents…
Michelle Scott, PhD
Department of Biochemistry, Université de Sherbrooke Characterization of a novel function of small RNAs in alternative splicing The process of alternative splicing allows the production of multiple distinct proteins from a single gene, in a manner that can be cell-type specific. Alternative splicing requires an extensive and complex regulation. Diverse human diseases can be caused…
